58 citations · 73 across the 7 of their papers we have counts for
7 papers
How genome redundancy can promote evolutionary innovation
Domenico Caudo, Mattia Miotto, Giancarlo Ruocco +1
Polyploidy is defined as the existence of more than two complete sets of homologous chromosomes. Despite it being a widespread phenomenon across the tree of life, its role as eithe…
Deciphering the chemical grammar of protein-RNA condensates
Greta Grassmann, Giancarlo Ruocco, Mattia Miotto
Biomolecular phase separation is typically attributed to the polymer physics of long, disordered chains. However, the underlying chemical grammar, i.e. the specific interactions be…
Insights into the role of dynamical features in protein complex formation: the case of SARS-CoV-2 spike binding with ACE2
Greta Grassmann, Mattia Miotto, Francesca Alessandrini +4
The functionality of protein-protein complexes is closely tied to the strength of their interactions, making the evaluation of binding affinity a central focus in structural biolog…
Compact assessment of molecular surface complementarities enhances neural network-aided prediction of key binding residues
Greta Grassmann, Lorenzo Di Rienzo, Giancarlo Ruocco +2
Predicting interactions between biomolecules, such as protein-protein complexes, remains a challenging problem. Despite the many advancements done so far, the performances of docki…
Electrostatic complementarity at the interface drives transient protein-protein interactions
Greta Grassmann, Lorenzo Di Rienzo, Giorgio Gosti +4
Understanding the molecular mechanisms driving the binding between bio-molecules is a crucial challenge in molecular biology. In this respect, characteristics like the preferential…
A computational approach to investigate TDP-43 C-terminal fragments aggregation in Amyotrophic Lateral Sclerosis
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +7
Many of the molecular mechanisms underlying the pathological aggregation of proteins observed in neurodegenerative diseases are still not fully understood. Among the diseases assoc…
New algorithm to determine a minimal representation of the molecular surface
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +3
Most proteins perform their biological function by interacting with one or more molecular partners. In this respect, characterizing the features of the molecular surface, especiall…