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stat.ME2021
On matching-adjusted indirect comparison and calibration estimation
Jixian Wang
Indirect comparisons have been increasingly used to compare data from different sources such as clinical trials and observational data in, e.g., a disease registry. To adjust for p…
stat.ME2021
Improving the Performance of Bayesian Logistic Regression Model with Overdose Control in Oncology Dose-Finding Studies
Hongtao Zhang, Alan Y Chiang, Jixian Wang
An accurately identified maximum tolerated dose (MTD) serves as the cornerstone of successful subsequent phases in oncology drug development. Bayesian logistic regression model (BL…