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Weighting Based Approaches to Borrowing Historical Controls for Indirect comparison for Time-to-Event Data with a Cure Fraction
Jixian Wang, Hongtao Zhang, Ram Tiwari
To use historical controls for indirect comparison with single-arm trials, the population difference between data sources should be adjusted to reduce confounding bias. The adjustm…
A Propensity-Score Integrated Approach to Bayesian Dynamic Power Prior Borrowing
Jixian Wang, Hongtao Zhang, Ram Tiwari
Use of historical control data to augment a small internal control arm in a randomized control trial (RCT) can lead to significant improvement of the efficiency of the trial. It in…
On matching-adjusted indirect comparison and calibration estimation
Jixian Wang
Indirect comparisons have been increasingly used to compare data from different sources such as clinical trials and observational data in, e.g., a disease registry. To adjust for p…
Improving the Performance of Bayesian Logistic Regression Model with Overdose Control in Oncology Dose-Finding Studies
Hongtao Zhang, Alan Y Chiang, Jixian Wang
An accurately identified maximum tolerated dose (MTD) serves as the cornerstone of successful subsequent phases in oncology drug development. Bayesian logistic regression model (BL…