4 papers
Control systems for synthetic biology and a case-study in cell fate reprogramming
Domitilla Del Vecchio
This paper gives an overview of the use of control systems engineering in synthetic biology, motivated by applications such as cell therapy and cell fate reprogramming for regenera…
Contraction Dynamics in Heterogeneous Spatial Environments
Carlos Barajas, Jean-Jacques Slotine, Domitilla Del Vecchio
Understanding the asymptotic behavior of reaction-diffusion (RD) systems is crucial for modeling processes ranging from species coexistence in ecology to biochemical interactions w…
Multi-variable control to mitigate loads in CRISPRa networks: Extended Version
Krishna Manoj, Theodore W. Grunberg, Domitilla Del Vecchio
The discovery of CRISPR-mediated gene activation (CRISPRa) has transformed the way in which we perform genetic screening, bioproduction and therapeutics through its ability to scal…
What Is the Trait d'Union between Retroactivity and Molecular Communication Performance Limits?
Francesca Ratti, Maurizio Magarini, Domitilla Del Vecchio
Information exchange is a critical process in all communication systems, including biological ones. The concept of retroactivity represents the loads that downstream modules apply…