2 papers
q-bio.QM2026
Smooth MinMax: A Differentiable Relaxation for Codon Harmonization
Yoonho Jeong, Hyunwoo Choi, Ryan Fernandez Medina Hariri +3
Codon harmonization aims to adapt the coding sequences for heterologous expression while preserving the native-like patterns of frequent and rare codons that may influence local tr…
q-bio.QM2026
MOSAIC: Codon Harmonization of Monte Carlo-Based Simulated Annealing for Linked Codons in Heterologous Protein Expression
Yoonho Jeong, Chengcheng Yang, Ryan Fernandez Medina Hariri +6
Codon usage bias has a crucial impact on the translation efficiency and co-translational folding of proteins, necessitating the algorithmic development of codon optimization/harmon…