most citedBayesian Optimization for General Reaction Conditions

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cs.LG20262 cited

Bayesian Optimization for General Reaction Conditions

Stefan P. Schmid, Ella Miray Rajaonson, Cher Tian Ser +6

General chemical reaction conditions that achieve consistently high performance across multiple substrates are important for practical applications such as library synthesis and hi…

cs.LG2026

Generative Molecular Morphing for Flexible-Size Design via Unbalanced Optimal Transport

Malte Franke, Stefan P. Schmid, Zarko Ivkovic +2

The success of generative molecular design hinges on a model's steerability toward high-reward samples. Because many molecular properties are intrinsically linked to molecular size…

cs.LG2026

Constrained Flow Optimization via Sequential Fine Tuning for Molecular Design

Sven Gutjahr, Riccardo De Santi, Luca Schaufelberger +2

Adapting generative foundation models, in particular diffusion and flow models, to optimize given reward functions (e.g., binding affinity) while satisfying constraints (e.g., mole…

cs.LG2026

Bayesian Scattering: A Principled Baseline for Uncertainty on Image Data

Bernardo Fichera, Zarko Ivkovic, Kjell Jorner +2

Uncertainty quantification for image data is dominated by complex deep learning methods, yet the field lacks an interpretable, mathematically grounded baseline. We propose Bayesian…

cs.LG2026

Generating Cyclic Conformers with Flow Matching in Cremer-Pople Coordinates

Luca Schaufelberger, Aline Hartgers, Kjell Jorner

Cyclic molecules are ubiquitous across applications in chemistry and biology. Their restricted conformational flexibility provides structural pre-organization that is key to their…