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physics.bio-ph2025
Conformational Dynamics of 8-Oxoguanine Mispairing Reveal a Mechanism of Polymerase λ Misincorporation
George Ferguson, Louie Slocombe, Max Winokan +2
Experimental evidence has shown the stability of oxygen-stress-damaged guanine, known as 8-oxoguanine. This common oxygen-damaged nucleobase is often found in the presence of react…
physics.bio-ph2021
An Open Quantum Systems approach to proton tunnelling in DNA
Louie Slocombe, Marco Sacchi, Jim Al-Khalili
One of the most important topics in molecular biology is the genetic stability of DNA. One threat to this stability is proton transfer along the hydrogen bonds of DNA that could le…