2 papers
q-bio.BM2024
PepDoRA: A Unified Peptide Language Model via Weight-Decomposed Low-Rank Adaptation
Leyao Wang, Rishab Pulugurta, Pranay Vure +3
Peptide therapeutics, including macrocycles, peptide inhibitors, and bioactive linear peptides, play a crucial role in therapeutic development due to their unique physicochemical p…
q-bio.BM2024
PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling
Tianlai Chen, Madeleine Dumas, Rio Watson +17
Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTA…