10 papers
Robust Quickest Change Detection with Cost-Efficient Experiment Design and Unknown Post-Change Model
Patrick Vincent Lubenia, Taposh Banerjee
A quickest change detection problem is studied where the decision-maker has access to multiple experiments, but can choose only one experiment at a time to detect the change. The t…
Quickest Change Detection with Cost-Constrained Experiment Design
Patrick Vincent N. Lubenia, Taposh Banerjee
In the classical quickest change detection problem, an observer performs a single experiment to monitor a stochastic process. The goal in the classical problem is to detect a chang…
The finest decompositions' architecture of a reaction network
Bryan S. Hernandez, Juan Paolo C. Santos, Patrick Vincent N. Lubenia +1
Biochemical and environmental modeling typically relies on reaction networks to represent complex transformations. While the Linkage Class Decomposition (LCD) partitions networks b…
Comparison of reaction networks of insulin signaling
Patrick Vincent N. Lubenia, Eduardo R. Mendoza, Angelyn R. Lao
Understanding the insulin signaling cascade provides insights on the underlying mechanisms of biological phenomena such as insulin resistance, diabetes, Alzheimer's disease, and ca…
Embedding-based comparison of reaction networks of Wnt signaling
Bryan S. Hernandez, Patrick Vincent N. Lubenia, Eduardo R. Mendoza
This work introduces a new method for comparing two reaction networks of the same or closely related systems through their embedded networks in terms of the shared set of species.…
Equilibria decomposition-based comparison of reaction networks of Wnt signaling
Bryan S. Hernandez, Patrick Vincent N. Lubenia, Eduardo R. Mendoza
The Wnt signaling pathway plays a critical role in various biochemical processes, including embryonic development, tissue homeostasis, and cancer progression. In this paper, we con…
Comparative Analysis of Kinetic Realizations of Insulin Signaling
Patrick Vincent N. Lubenia, Eduardo R. Mendoza, Angelyn R. Lao
Several studies have developed dynamical models to understand the underlying mechanisms of insulin signaling, a signaling cascade that leads to the translocation of glucose, the hu…
A decomposition-based approach for deriving positive steady states of a class of chemical reaction networks with non-mass-action kinetics
Bryan S. Hernandez, Patrick Vincent N. Lubenia
Steady states are frequently used to investigate the long-term behaviors of (bio)-chemical systems. Recently, there has been a growing interest in network-based approaches due to t…
Reaction Network Analysis of Metabolic Insulin Signaling
Patrick Vincent N. Lubenia, Eduardo R. Mendoza, Angelyn R. Lao
Absolute concentration robustness (ACR) and concordance are novel concepts in the theory of robustness and stability within Chemical Reaction Network Theory. In this paper, we have…
Concentration Robustness in LP Kinetic Systems
Angelyn R. Lao, Patrick Vincent N. Lubenia, Daryl M. Magpantay +1
For a reaction network with species set , a log-parametrized (LP) set is a non-empty set of the form $E(P, x^*) = \{x \in \mathbb{R}^\mathscr{S}_> \mid \log x - \log x…