2 papers
stat.AP2026
A Bayesian predictive framework for adaptive interim-analysis timing with robust borrowing in confirmatory trials
Meihua Long, Tianyu Zheng, Jiali Song +4
Confirmatory phase III trials require rigorous evidence, yet for first-in-class (FIC) therapies they must often be designed when same-mechanism evidence is scarce. This uncertainty…
stat.AP2026
A Workflow for Evaluating Regional Treatment Effect Heterogeneity in Multi-Regional Clinical Trials
Cong Zhang, Meihua Long, Tianyu Zheng +8
Multi-regional clinical trials (MRCTs) enable efficient global drug development by assessing treatment effects across regions within a single protocol. While powered for overall ef…