5 papers
Control Laws in Aging and Longevity: A Control Theory of Aging for Gerotherapeutic Drug Discovery
Alex Zhavoronkov, Bud Mishra
Existing aging theories describe what changes with age but do not prescribe how to intervene. We propose a control-theoretic framework that is not merely descriptive but prescripti…
Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Alex Zhavoronkov, Dominika Wilczok
The unprecedented extension of the human lifespan necessitates a parallel evolution in how we quantify the quality of aging and its socioeconomic impact. Traditional metrics focusi…
The Right to Be Remembered: Preserving Maximally Truthful Digital Memory in the Age of AI
Alex Zhavoronkov, Dominika Wilczok, Roman Yampolskiy
Since the rapid expansion of large language models (LLMs), people have begun to rely on them for information retrieval. While traditional search engines display ranked lists of sou…
Engineering the Future of R&D: The Case for AI-Driven, Integrated Biotechnology Ecosystems
Alex Zhavoronkov, Chuen Yan Leung
The escalating cost, extended timelines, and low success rates in pharmaceutical research demand a fundamental rethinking of biotechnology R&D infrastructure. This chapter introduc…
Enhancing Drug Discovery: Quantum Machine Learning for QSAR Prediction with Incomplete Data
Wei-Yin Chiang, Po-Yu Kao, Tzu-Lan Yeh +3
Qualitative structure-activity relationship (QSAR) is important for drug discovery and offers valuable insights into the biological interactions of potential drug candidates. It ha…