6 papers
Biophysics of the Pyrenoid
Charley Schaefer, Mark Leake
Phase-separated liquid droplets organize molecules in cells, but the underlying physical principles differ from abiotic mixing and quantitative rules in living systems remain poorl…
Protein Dynamics Beyond Structure Prediction
Juliette Griffié, Sviatlana Shashkova, Antonio Ciarlo +41
The ability to predict protein three-dimensional structures from amino acid sequences is a landmark achievement in molecular biology, where recent deep learning approaches such as…
The Integration Host Factor is a pH-responsive protein that switches from DNA bending to DNA bridging in acidic biofilm-like conditions
Dinesh Parthasarathy, Saminathan Ramakrishnan, Georgia Tsang +9
The Integration Host Factor (IHF) is a nucleoid-associated protein critical for both DNA compaction and biofilm stability. While its role in DNA packaging within the cell is well u…
The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
Jamieson A L Howard, Benjamin Ambrose, Mahmoud A S Abdelhamid +10
DNA helicases undergo conformational changes; however, their structural dynamics are poorly understood. Here, we study single molecules of superfamily 1A DNA helicase Rep, which un…
Single-molecule biophysics
Mark C Leake
Biological molecules, like all active matter, use free energy to generate force and motion which drive them out of thermal equilibrium, and undergo inherent dynamic interconversion…
Invention, Innovation, and Commercialisation in British Biophysics
Jack Shepherd, Mark Leake
British biophysics has a tradition of scientific invention and innovation, resulting in new technologies transforming biological insight, such as rapid DNA sequencing, super-resolu…