3 papers
Multi-Large Language Model Orchestrated Severity Assessment of Clinical Records (MOSAIC)
Manuela Del Castillo Suero, Arnault-Quentin Vermillet, Nicole Sonne Heckmann +2
Background: Disease severity is a multidimensional construct difficult to capture with rule-based approaches in Electronic Healthcare Records (EHR). Agentic large language model (L…
Optimizing Large Language Models for Causality Assessment in Pharmacovigilance: Developing a Performance Metric as Objective for Bayesian Hyperparameter Optimization
Nicole Sonne Heckmann, Arnault-Quentin Vermillet, Søren Norlin Mølgaard +4
Background: Growing individual case safety report (ICSR) volumes have intensified demand for scalable automated causality assessment. Large Language Models (LLMs) show promise, yet…
Employing General-Purpose and Biomedical Large Language Models with Advanced Prompt Engineering for Pharmacoepidemiologic Study Design
Xinyao Zhang, Nicole Sonne Heckmann, Manuela Del Castillo Suero +2
Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains…