4 papers
Multistationarity in semi-open Phosphorylation-Dephosphorylation Cycles
Praneet Nandan, Beatriz Pascual-Escudero, Diego Rojas La Luz
Multistationarity, underlies biochemical switching and cellular decision-making. We study how multistationarity in the sequential n-site phosphorylation-dephosphorylation cycle is…
Optimization of sequential therapies to maximize extinction of resistant bacteria through collateral sensitivity
Javier Molina-Hernández, José A. Cuesta, Beatriz Pascual-Escudero +2
Antimicrobial resistance (AMR) threatens global health. A promising and underexplored strategy to tackle this problem is sequential therapies exploiting collateral sensitivity (CS)…
The generic geometry of steady state varieties
Elisenda Feliu, Oskar Henriksson, Beatriz Pascual-Escudero
We answer several fundamental geometric questions about reaction networks with power-law kinetics, on topics such as generic finiteness of the number of steady states, robustness,…
Nash multiplicity sequences and Hironaka's order function
A. Bravo, S. Encinas, B. Pascual-Escudero
When is a -dimensional variety defined over a field of characteristic zero, a constructive resolution of singularities can be achieved by successively lowering the maxim…