10 papers
Modern view of activated rate processes: unidirectional fluxes at equilibrium, correlation functions, and splitting probabilities
Alexander M. Berezhkovskii, Kevin Song, Dmitrii E. Makarov
More than 80 years ago Kramers published a paper calculating how fast a Brownian particle escapes from a potential well over an activation barrier. Since then Kramers' model has be…
Speed limits on biomolecular processes from fundamental physical constants
Dmitrii E Makarov
Many of the timescales of life have speed limits set by quantum-mechanical constraints along with non-fundamental quantities, such as the temperature of the environment, which are…
Thermodynamic inference from noisy single-molecule time series
Todd R. Gingrich, Oleg A. Igoshin, Anatoly B. Kolomeisky +1
Single-molecule or single-particle tracking measurements inherently yield noisy microscopic trajectories, often significantly constrained by the diffraction limit and by the finite…
Energy Barriers for Reversible Chain Scission and Healing under Tension with Displacement Control
Mohammad A. Ansari, Kenneth M. Liechti, Dmitrii E. Makarov +1
Polymer chain scission is a key mechanism for fracture of soft materials. It is well known from single-molecule force spectroscopy experiments that the critical condition for chain…
Quantum Transition Rates in Arbitrary Physical Processes
Adolfo del Campo, András Grabarits, Dmitrii Makarov +1
We introduce a framework for computing time-dependent quantum transition rates (QTRs) that describe the pace of evolution of a quantum state from a given subspace to a target subsp…
Towards Markov-State Holography
Xizhu Zhao, Dmitrii E. Makarov, Aljaž Godec
Experiments, in particular on biological systems, typically probe lower-dimensional observables which are projections of high-dimensional dynamics. In order to infer consistent mod…