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Patient-perceived progression in multiple system atrophy: natural history of quality of life
Tiphaine Saulnier, Margherita Fabbri, Mélanie Le Goff +6
Health-related quality of life (Hr-QoL) scales provide crucial information on neurodegenerative disease progression, help improving patient care, and constitute a meaningful endpoi…
Random Forests for time-fixed and time-dependent predictors: The DynForest R package
Anthony Devaux, Cécile Proust-Lima, Robin Genuer
The R package DynForest implements random forests for predicting a continuous, a categorical or a (multiple causes) time-to-event outcome based on time-fixed and time-dependent pre…
Disease progression model anchored around clinical diagnosis in longitudinal cohorts: example of Alzheimer's disease and related dementia
Jérémie Lespinasse, Carole Dufouil, Cécile Proust-Lima +1
Background. Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo clinical changes. Yet, modeling changes over disease course from c…
Analysis of the 24-Hour Activity Cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought (ACT) Study
Yinxiang Wu, Dori E. Rosenberg, Mikael Anne Greenwood-Hickman +7
The 24-hour activity cycle (24HAC) is a new paradigm for studying activity behaviors in relation to health outcomes. This approach captures the interrelatedness of the daily time s…