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Analysis of the 24-Hour Activity Cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought (ACT) Study
Yinxiang Wu, Dori E. Rosenberg, Mikael Anne Greenwood-Hickman +7
The 24-hour activity cycle (24HAC) is a new paradigm for studying activity behaviors in relation to health outcomes. This approach captures the interrelatedness of the daily time s…
Describing complex disease progression using joint latent class models for multivariate longitudinal markers and clinical endpoints
Cécile Proust-Lima, Tiphaine Saulnier, Viviane Philipps +5
Neurodegenerative diseases are characterized by numerous markers of progression and clinical endpoints. For instance, Multiple System Atrophy (MSA), a rare neurodegenerative synucl…
Dynamic Modelling of Multivariate Dimensions and Their Temporal Relationships using Latent Processes: Application to Alzheimer's Disease
Bachirou O. Taddé, Hélène Jacqmin-Gadda, Jean-François Dartigues +2
Alzheimer's disease gradually affects several components including the cerebral dimension with brain atrophies, the cognitive dimension with a decline in various functions and the…
Individual dynamic predictions using landmarking and joint modelling: validation of estimators and robustness assessment
Loïc Ferrer, Hein Putter, Cécile Proust-Lima
After the diagnosis of a disease, one major objective is to predict cumulative probabilities of events such as clinical relapse or death from the individual information collected u…
Joint modelling of longitudinal and multi-state processes: application to clinical progressions in prostate cancer
Loïc Ferrer, Virginie Rondeau, James J. Dignam +3
Joint modelling of longitudinal and survival data is increasingly used in clinical trials on cancer. In prostate cancer for example, these models permit to account for the link bet…
Joint modelling of repeated multivariate cognitive measures and competing risks of dementia and death: a latent process and latent class approach
Cécile Proust-Lima, Jean-François Dartigues, Hélène Jacqmin-Gadda
Joint models initially dedicated to a single longitudinal marker and a single time-to-event need to be extended to account for the rich longitudinal data of cohort studies. Multipl…