2 papers
stat.ME2022
Generating the right evidence at the right time: Principles of a new class of flexible augmented clinical trial designs
Cornelia Dunger-Baldauf, Rob Hemmings, Frank Bretz +3
The past few years have seen an increasing number of initiatives aimed at integrating information generated outside of confirmatory randomised clinical trials (RCTs) into drug deve…
stat.ME2018
Properties of the weighted log-rank test in the design of confirmatory studies with delayed effects
Jose L Jimenez, Viktoriya Stalbovskaya, Byron Jones
Proportional hazards are a common assumption when designing confirmatory clinical trials in oncology. This assumption not only affects the analysis part but also the sample size ca…