293 citations · 783 across the 7 of their papers we have counts for
7 papers
How different are self and nonself?
Andreas Mayer, Jonathan A. Levine, Christopher J. Russo +3
Biological and artificial networks routinely make reliable distinctions between similar inputs, and the rules for making these distinctions are learned. In some ways, self/nonself…
Genesis of the alpha beta T-cell receptor
Thomas Dupic, Quentin Marcou, Aleksandra M. Walczak +1
The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called and , to recognize pathogens. Using results of high throughput sequencing and…
IGoR: a tool for high-throughput immune repertoire analysis
Quentin Marcou, Thierry Mora, Aleksandra M Walczak
High throughput immune repertoire sequencing is promising to lead to new statistical diagnostic tools for medicine and biology. Successful implementations of these methods require…
A model for the integration of conflicting exogenous and endogenous signals by dendritic cells
Quentin Marcou, Irit Carmi-Levy, Coline Trichot +3
Cells of the immune system are confronted with opposing pro- and anti-inflammatory signals. Dendritic cells (DC) integrate these cues to make informed decisions whether to initiate…
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
Mikhail V. Pogorelyy, Yuval Elhanati, Quentin Marcou +9
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequen…
repgenHMM: a dynamic programming tool to infer the rules of immune receptor generation from sequence data
Yuval Elhanati, Quentin Marcou, Thierry Mora +1
The diversity of the immune repertoire is initially generated by random rearrangements of the receptor gene during early T and B cell development. Rearrangement scenarios are compo…
Inferring processes underlying B-cell repertoire diversity
Yuval Elhanati, Zachary Sethna, Quentin Marcou +3
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-…