10 papers
Robust Topologically Protected Edge Transport in Doubly Chiral Active Particles
Tristan Edwards, Maxim Nikolaev, Jaime Agudo-Canalejo
Using theory, simulation, and experiment, we introduce a new class of active particle which we term doubly chiral active Brownian particles (dcABPs), which show robust topologicall…
Topological edge currents promote exploratory chromosome capture in microtubule dynamic instability
Chongbin Zheng, Jaime Agudo-Canalejo, Jonathon Howard +1
Microtubules capture chromosomes during mitosis by stochastically switching between growth and shrinkage at catastrophe events. They display strikingly rich biochemistry and dynami…
Nonequilibrium protein complexes as molecular automata
Jan Kocka, Kabir Husain, Jaime Agudo-Canalejo
Biology stores information and computes at the molecular scale, yet the ways in which it does so are often distinct from human-engineered computers. Mapping biological computation…
Spatial self-organization of enzymes in complex reaction networks
Vincent Ouazan-Reboul, Ramin Golestanian, Jaime Agudo-Canalejo
Living systems contain intricate biochemical networks whose structure is closely related to their function and allows them to exhibit robust behavior in the presence of external st…
Topological phases in discrete stochastic systems
Jaime Agudo-Canalejo, Evelyn Tang
Topological invariants have proved useful for analyzing emergent function as they characterize a property of the entire system, and are insensitive to local details, disorder, and…
Mechanistic rules for de novo design of enzymes
Michalis Chatzittofi, Jaime Agudo-Canalejo, Ramin Golestanian
Enzymes are nano-scale machines that have evolved to drive chemical reactions out of equilibrium in the right place at the right time. Given the complexity and specificity of enzym…