5 papers
Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis
Mohammed Akli Ayoub, Romain Yvinec, Gwenhaël Jégot +5
Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric…
Advances in computational modeling approaches in pituitary gonadotropin signaling
Romain Yvinec, Pascale Crépieux, Eric Reiter +2
Pituitary gonadotropins play an essential and pivotal role in the control of human and animal reproduction within the hypothalamic-pituitary-gonadal (HPG) axis. The computational m…
Follicle-stimulating hormone receptor: Advances and remaining challenges
Francesco De Pascali, Aurélie Tréfier, Flavie Landomiel +6
Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of…
Computational modeling approaches in gonadotropin signaling
Mohammed Akli Ayoub, Romain Yvinec, Pascale Crépieux +1
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) play essential roles in animal reproduction. They exert their function through binding to their cognate receptors, w…
Workflow description to dynamically model β-arrestin signaling networks
Romain Yvinec, Mohammed Akli Ayoub, Francesco De Pascali +3
Dynamic models of signaling networks allow the formulation of hypotheses on the topology and kinetic rate laws characterizing a given molecular network, in-depth exploration and co…