3 papers
physics.bio-ph2022
Systematic conformation-to-phenotype mapping via limited deep-sequencing of proteins
Eugene Serebryany, Victor Y. Zhao, Kibum Park +4
Non-native conformations drive protein misfolding diseases, complicate bioengineering efforts, and fuel molecular evolution. No current experimental technique is well-suited for el…
q-bio.GN2018
Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation
Bogdan Budnik, Ezra Levy, Guillaume Harmange +1
Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of e…
q-bio.QM2017
Quantifying homologous proteins and proteoforms
Dmitry Malioutov, Tianchi Chen, Jacob Jaffe +4
Many proteoforms - arising from alternative splicing, post-translational modifications (PTMs), or paralogous genes - have distinct biological functions, such as histone PTM proteof…