5 papers
Miniature work-to-work converter engine powered by motor protein
Suraj Deshmukh, Sougata Guha, Basudha Roy +3
Designing a miniature microscale engine that can override the role of thermal fluctuations has remained elusive and is an important open challenge. Here we provide the design and t…
Nature of barriers determine first passage times in heterogeneous media
Moumita Dasgupta, Sougata Guha, Leon Armbruster +2
Intuition suggests that passage times across a region increases with the number of barriers along the path. Can this fail depending on the nature of the barrier? To probe this fund…
Theoretical analysis of cargo transport by catch bonded motors in optical trapping assays
Naren Sundararajan, Sougata Guha, Sudipto Muhuri +1
Dynein motors exhibit catch bonding, where the unbinding rate of the motors from microtubule filaments decreases with increasing opposing load. The implications of this catch bond…
Novel Catchbond mediated oscillations in motor-microtubule complexes
Sougata Guha, MIthun K. Mitra, Ignacio Pagonabarraga +1
Generation of mechanical oscillation is ubiquitous to wide variety of intracellular processes. We show that catchbonding behaviour of motor proteins provides a generic mechanism of…
Stabilization of overlapping biofilaments by passive crosslinkers
Sougata Guha, Subhadip Ghosh, Ignacio Pagonabarraga +1
The formation, maintenance and reorganization of the cytoskeletal filament network is essential for a number of cellular processes. While the crucial role played by active forces g…