19 citations · 19 across the 3 of their papers we have counts for
4 papers
Quantifying "just-right" APC inactivation for colorectal cancer initiation
Meritxell Brunet Guasch, Nathalie Feeley, Ignacio Soriano +4
Dysregulation of the tumour suppressor gene Adenomatous Polyposis Coli (APC) is a canonical step in colorectal cancer development. Curiously, most colorectal tumours carry bialleli…
Sequential mutations in exponentially growing populations
Michael D. Nicholson, David Cheek, Tibor Antal
Stochastic models of sequential mutation acquisition are widely used to quantify cancer and bacterial evolution. Across manifold scenarios, recurrent research questions are: how ma…
Competing evolutionary paths in growing populations with applications to multidrug resistance
Michael D. Nicholson, Tibor Antal
Investigating the emergence of a particular cell type is a recurring theme in models of growing cellular populations. The evolution of resistance to therapy is a classic example. C…
Universal asymptotic clone size distribution for general population growth
Michael D. Nicholson, Tibor Antal
Deterministically growing (wild-type) populations which seed stochastically developing mutant clones have found an expanding number of applications from microbial populations to ca…