2 papers
stat.ME2018
A Bayesian seamless phase I-II trial design with two stages for cancer clinical trials with drug combinations
José L. Jiménez, Sungjin Kim, Mourad Tighiouart
The use of drug combinations in clinical trials is increasingly common during the last years since a more favorable therapeutic response may be obtained by combining drugs. In phas…
stat.ME2018
Properties of the weighted log-rank test in the design of confirmatory studies with delayed effects
Jose L Jimenez, Viktoriya Stalbovskaya, Byron Jones
Proportional hazards are a common assumption when designing confirmatory clinical trials in oncology. This assumption not only affects the analysis part but also the sample size ca…