4 papers
Using systemic modeling and Bayesian calibration to investigate the role of the tumor microenvironment on chemoresistance
Sabrina Schönfeld, Laura Scarabosio, Alican Ozkan +2
Using a novel modeling approach based on the so-called environmental stress level (ESL), we develop a mathematical model to describe systematically the collective influence of oxyg…
Environmental stress level to model tumor cell growth and survival
Sabrina Schönfeld, Alican Ozkan, Laura Scarabosio +2
Survival of living tumor cells underlies many influences such as nutrient saturation, oxygen level, drug concentrations or mechanical forces. Data-supported mathematical modeling c…
Mixture theory modeling for characterizing solute transport in breast tumor tissues
Sreyashi Chakraborty, Alican Ozkan, Marissa Nichole Rylander +2
Solute transport is modeled using mixture theory, applied to the nanoparticle accumulation and concentration decay in the tissue space for different vascular configurations. A comp…
In Vitro Vascularized Liver and Tumor Tissue Microenvironments on a Chip for Dynamic Determination of Nanoparticle Transport and Toxicity
Alican Ozkan, Neda Ghousifam, P. Jack Hoopes +1
This paper presents the development of a vascularized breast tumor and healthy or tumorigenic liver microenvironments-on-a-chip connected in series. This is the first description o…