33 citations · 34 across the 3 of their papers we have counts for
3 papers
q-bio.QM2024
A computational framework for optimal and Model Predictive Control of stochastic gene regulatory networks
Hamza Faquir, Manuel Pájaro, Irene Otero-Muras
Engineering biology requires precise control of biomolecular circuits, and Cybergenetics is the field dedicated to achieving this goal. A significant challenge in developing contro…
q-bio.MN2018★ 33 cited
Transient hysteresis and inherent stochasticity in gene regulatory networks
Manuel Pájaro, Irene Otero-Muras, Carlos Vázquez +1
Cell fate determination, the process through which cells commit to differentiated states is commonly mediated by gene regulatory motifs with mutually exclusive expression states. T…
math.OC2014★ 1 cited
Multicriteria global optimization for biocircuit design
Irene Otero-Muras, Julio R. Banga
One of the challenges in Synthetic Biology is to design circuits with increasing levels of complexity. While circuits in Biology are complex and subject to natural tradeoffs, most…