3 papers
math.DS2026
Predictive-Switching Control of Stochastic Gene Regulatory Networks: A Contractive PIDE Framework
Christian Fernández, Manuel Pájaro, Gábor Szederkényi +1
This paper develops a predictive switching control algorithm for stochastic gene regulatory networks described by a Partial Integro-Differential Equation (PIDE) model, which enable…
q-bio.QM2024
A computational framework for optimal and Model Predictive Control of stochastic gene regulatory networks
Hamza Faquir, Manuel Pájaro, Irene Otero-Muras
Engineering biology requires precise control of biomolecular circuits, and Cybergenetics is the field dedicated to achieving this goal. A significant challenge in developing contro…
q-bio.MN2018
Transient hysteresis and inherent stochasticity in gene regulatory networks
Manuel Pájaro, Irene Otero-Muras, Carlos Vázquez +1
Cell fate determination, the process through which cells commit to differentiated states is commonly mediated by gene regulatory motifs with mutually exclusive expression states. T…