71 citations · 182 across the 11 of their papers we have counts for
9 papers · 1 filter
The Fluid Mechanics of Truncus Arteriosus
Karoline-Marie Bornemann, Perry S. Choi, Jay A. Huber +7
Truncus arteriosus (TA) is a rare, severe congenital heart disease in which the two main arteries exiting the heart fail to separate in utero resulting in one truncus and truncal v…
Simulations Predict Improved Valve Performance Without Direct Leaflet Intervention After Neonatal Truncus Arteriosus Repair
Karoline-Marie Bornemann, Perry S. Choi, Jay Huber +6
Truncus arteriosus (TA) is a rare and severe congenital heart disease. Quadricuspid valve morphology occurs in 25% of all TA patients and is linked to regurgitation and increased r…
A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve
Alexander D. Kaiser, Jing Wang, Aaron L. Brown +3
The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental…
Simulation-Based Design of Bicuspidization of the Aortic Valve
Alexander D. Kaiser, Moussa A. Haidar, Perry S. Choi +3
Objective: Severe congenital aortic valve pathology in the growing patient remains a challenging clinical scenario. Bicuspidization of the diseased aortic valve has proven to be a…
Modeling the Mitral Valve
Alexander D. Kaiser
This thesis is concerned with modeling and simulation of the mitral valve, one of the four valves in the human heart. The valve is composed of leaflets attached to a ring, the free…
Comparison of Immersed Boundary Simulations of Heart Valve Hemodynamics against In Vitro 4D Flow MRI Data
Alexander D. Kaiser, Nicole K. Schiavone, Christopher J. Elkins +3
The immersed boundary (IB) method is a mathematical framework for fluid-structure interaction problems (FSI) that was originally developed to simulate flows around heart valves. Di…
Controlled Comparison of Simulated Hemodynamics across Tricuspid and Bicuspid Aortic Valves
Alexander D. Kaiser, Rohan Shad, Nicole Schiavone +2
Bicuspid aortic valve is the most common congenital heart defect, affecting 1-2% of the global population. Patients with bicuspid valves frequently develop dilation and aneurysms o…
A Design-Based Model of the Aortic Valve for Fluid-Structure Interaction
Alexander D. Kaiser, Rohan Shad, William Hiesinger +1
This paper presents a new method for modeling the mechanics of the aortic valve, and simulates its interaction with blood. As much as possible, the model construction is based on f…
Modeling the Mitral Valve
Alexander D. Kaiser, David M. McQueen, Charles S. Peskin
This work is concerned with modeling and simulation of the mitral valve, one of the four valves in the human heart. The valve is composed of leaflets, the free edges of which are s…