24 citations · 42 across the 9 of their papers we have counts for
9 papers
Dark energy: the cost of function in protein evolution
Ezequiel A. Galpern, Federico Caamaño, Ignacio E. Sánchez +1
The evolutionary fate of proteins is driven by both folding stability and biological function, dual constraints that often conflict, creating frustration and imposing functional co…
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
Predicting protein folding dynamics using sequence information
Ezequiel A. Galpern, Federico Caamaño, Diego U. Ferreiro
Natural protein sequences somehow encode the structural forms that these molecules adopt. Recent developments in structure-prediction are agnostic to the mechanisms by which protei…
Inferring protein folding mechanisms from natural sequence diversity
Ezequiel A. Galpern, Ernesto A. Roman, Diego U. Ferreiro
Protein sequences serve as a natural record of the evolutionary constraints that shape their functional structures. We show that it is possible to use only sequence information to…
Reassessing the Exon-Foldon correspondence using Frustration Analysis
Ezequiel A. Galpern, Hana Jaafari, Carlos Bueno +2
Protein folding and evolution are intimately linked phenomena. Here, we revisit the concept of exons as potential protein folding modules across 38 abundant and conserved protein f…
Solvent constraints for biopolymer folding and evolution in extraterrestrial environments
Ignacio E. Sánchez, Ezequiel A. Galpern, Diego U. Ferreiro
We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to…
Molecular information theory meets protein folding
Ignacio E. Sánchez, Ezequiel A. Galpern, Martín M. Garibaldi +1
We propose an application of molecular information theory to analyze the folding of single domain proteins. We analyze results from various areas of protein science, such as sequen…
From evolution to folding of repeat proteins
Ezequiel A. Galpern, Jacopo Marchi, Thierry Mora +2
Repeat proteins are made with tandem copies of similar amino acid stretches that fold into elongated architectures. Due to their symmetry, these proteins constitute excellent model…
Size and structure of the sequence space of repeat proteins
Jacopo Marchi, Ezequiel A. Galpern, Rocio Espada +3
The coding space of protein sequences is shaped by evolutionary constraints set by requirements of function and stability. We show that the coding space of a given protein family--…