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physics.bio-ph2022
Compressive Instabilities Enable Cell-Induced Extreme Densification Patterns in the Fibrous Extracellular Matrix: Discrete Model Predictions
Chrysovalantou Kalaitzidou, Georgios Grekas, Andreas Zilian +2
Through modelling and simulations we show that material instabilities play a dominant role in the mechanical behavior of the fibrous collagen Extracellular Matrix (ECM), as observe…
physics.bio-ph2019
Cells exploit a phase transition to mechanically remodel the fibrous extracellular matrix
Georgios Grekas, Maria Proestaki, Phoebus Rosakis +3
Through mechanical forces, biological cells remodel the surrounding collagen network, generating striking deformation patterns. Tethers-tracts of high densification and fiber align…