activity
20162025
most citedClarifying causal mediation analysis for the applied researcher: Defining effects based on what we want to learn

220 citations · 393 across the 14 of their papers we have counts for

collaborators

17 papers

stat.AP2025

Precision Mental Health: Predicting Heterogeneous Treatment Effects for Depression through Data Integration

Carly L. Brantner, Trang Quynh Nguyen, Harsh Parikh +3

When treating depression, clinicians are interested in determining the optimal treatment for a given patient, which is challenging given the amount of treatments available. To adva…

stat.ME2025

A Cautionary Tale on Integrating Studies with Disparate Outcome Measures for Causal Inference

Harsh Parikh, Trang Quynh Nguyen, Elizabeth A. Stuart +2

Data integration approaches are increasingly used to enhance the efficiency and generalizability of studies. However, a key limitation of these methods is the assumption that outco…

stat.ME2024

Self-separated and self-connected models for mediator and outcome missingness in mediation analysis

Trang Quynh Nguyen, Razieh Nabi, Fan Yang +2

Missing data is a common challenge in studying treatment effects. In the context of mediation analysis, this paper addresses missingness in the mediator and outcome, focusing on id…

stat.AP2024★ 4 cited

Practical challenges in mediation analysis: A guide for applied researchers

Megan S. Schuler, Donna L. Coffman, Elizabeth A. Stuart +3

Mediation analysis is a statistical approach that can provide insights regarding the intermediary processes by which an intervention or exposure affects a given outcome. Mediation…

stat.ME2023★ 3 cited

Identification of complier and noncomplier average causal effects in the presence of latent missing-at-random (LMAR) outcomes: a unifying view and choices of assumptions

Trang Quynh Nguyen, Michelle C. Carlson, Elizabeth A. Stuart

The study of treatment effects is often complicated by noncompliance and missing data. In the one-sided noncompliance setting where of interest are the complier and noncomplier ave…

stat.ME2023

Methods for Integrating Trials and Non-Experimental Data to Examine Treatment Effect Heterogeneity

Carly Lupton Brantner, Ting-Hsuan Chang, Trang Quynh Nguyen +3

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with p…

stat.ME2023

Comparison of Methods that Combine Multiple Randomized Trials to Estimate Heterogeneous Treatment Effects

Carly Lupton Brantner, Trang Quynh Nguyen, Tengjie Tang +3

Individualized treatment decisions can improve health outcomes, but using data to make these decisions in a reliable, precise, and generalizable way is challenging with a single da…

stat.ME2023★ 4 cited

Sensitivity analysis for principal ignorability violation in estimating complier and noncomplier average causal effects

Trang Quynh Nguyen, Elizabeth A. Stuart, Daniel O. Scharfstein +1

An important strategy for identifying principal causal effects, which are often used in settings with noncompliance, is to invoke the principal ignorability (PI) assumption. As PI…

stat.ME2023★ 8 cited

Multiple imputation for propensity score analysis with covariates missing at random: some clarity on within and across methods

Trang Quynh Nguyen, Elizabeth A. Stuart

In epidemiology and social sciences, propensity score methods are popular for estimating treatment effects using observational data, and multiple imputation is popular for handling…

stat.ME2021★ 13 cited

Causal mediation analysis: From simple to more robust strategies for estimation of marginal natural (in)direct effects

Trang Quynh Nguyen, Elizabeth L. Ogburn, Ian Schmid +4

This paper aims to provide practitioners of causal mediation analysis with a better understanding of estimation options. We take as inputs two familiar strategies (weighting and mo…

stat.ME2020★ 38 cited

Sensitivity analyses for effect modifiers not observed in the target population when generalizing treatment effects from a randomized controlled trial: Assumptions, models, effect scales, data scenarios, and implementation details

Trang Quynh Nguyen, Benjamin Ackerman, Ian Schmid +2

Background: Randomized controlled trials are often used to inform policy and practice for broad populations. The average treatment effect (ATE) for a target population, however, ma…

stat.ME2020★ 3 cited

Clarifying causal mediation analysis: Effect identification via three assumptions and five potential outcomes

Trang Quynh Nguyen, Ian Schmid, Elizabeth L. Ogburn +1

Causal mediation analysis is complicated with multiple effect definitions that require different sets of assumptions for identification. This paper provides a systematic explanatio…

stat.AP2019

Partially Pooled Propensity Score Models for Average Treatment Effect Estimation with Multilevel Data

Youjin Lee, Trang Q. Nguyen, Elizabeth A. Stuart

Causal inference analyses often use existing observational data, which in many cases has some clustering of individuals. In this paper we discuss propensity score weighting methods…

stat.ME2019★ 5 cited

Propensity score analysis with latent covariates: Measurement error bias correction using the covariate's posterior mean, aka the inclusive factor score

Trang Quynh Nguyen, Elizabeth A. Stuart

We address measurement error bias in propensity score (PS) analysis due to covariates that are latent variables. In the setting where latent covariate is measured via multiple…

stat.ME2019★ 220 cited

Clarifying causal mediation analysis for the applied researcher: Defining effects based on what we want to learn

Trang Quynh Nguyen, Ian Schmid, Elizabeth A. Stuart

The incorporation of causal inference in mediation analysis has led to theoretical and methodological advancements -- effect definitions with causal interpretation, clarification o…

stat.ME2016★ 79 cited

Sensitivity analysis for an unobserved moderator in RCT-to-target-population generalization of treatment effects

Trang Quynh Nguyen, Cyrus Ebnesajjad, Stephen R. Cole +1

In the presence of treatment effect heterogeneity, the average treatment effect (ATE) in a randomized controlled trial (RCT) may differ from the average effect of the same treatmen…

stat.ME2016★ 16 cited

The magnitude and direction of collider bias for binary variables

Trang Quynh Nguyen, Allan Dafoe, Elizabeth L. Ogburn

Suppose we are interested in the effect of variable on variable . If and both influence, or are associated with variables that influence, a common outcome, called a…