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q-bio.PE2025
Mendelian randomization in a multi-ancestry world: reflections and practical advice
Amy M. Mason, Verena Zuber, Gibran Hemani +8
Many Mendelian randomization (MR) papers have been conducted only in people of European ancestry, limiting transportability of results to the global population. Expanding MR to div…
stat.ME2025
Outlier Detection in Mendelian Randomisation
Maximilian M Mandl, Anne-Laure Boulesteix, Stephen Burgess +1
Mendelian Randomisation (MR) uses genetic variants as instrumental variables to infer causal effects of exposures on an outcome. One key assumption of MR is that the genetic varian…