4 papers
Understanding Protein-Complex Assembly through Grand Canonical Maximum Entropy Modeling
Andrei G. Gasic, Atrayee Sarkar, Margaret S. Cheung
Inside a cell, heterotypic proteins assemble in inhomogeneous, crowded systems where the abundance of these proteins vary with cell types. While some protein complexes form putativ…
A Tale of Two Desolvation Potentials: An Investigation of Protein Behavior Under High Hydrostatic Pressure
Andrei G. Gasic, Margaret S. Cheung
Hydrostatic pressure is a common perturbation to probe the conformations of proteins. There are two common forms of pressure dependent potentials of mean force (PMFs) derived from…
Critical phenomena in the temperature-pressure-crowding phase diagram of a protein
Andrei G. Gasic, Mayank M. Boob, Maxim B. Prigozhin +4
In the cell, proteins fold and perform complex functions through global structural rearrangements. Function requires a protein to be at the brink of stability to be susceptible to…
Crowding-induced Elongated Conformation of Urea-unfolded Apoazurin: Investigating the Role of Crowder Shape In Silico
Fabio C. Zegarra, Dirar Homouz, Andrei G. Gasic +4
Here, we show by solution nuclear magnetic resonance measurements that the urea-unfolded protein apoazurin becomes elongated when the synthetic crowding agent dextran 20 is present…