23 citations · 49 across the 4 of their papers we have counts for
4 papers
Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics
Rajat Desikan, Pranesh Padmanabhan, Andrzej M. Kierzek +1
The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine…
Application of Quantitative Systems Pharmacology to guide the optimal dosing of COVID-19 vaccines
Mario Giorgi, Rajat Desikan, Piet H. van der Graaf +1
Optimal use and distribution of Covid-19 vaccines involves adjustments of dosing. Due to the rapidly-evolving pandemic, such adjustments often need to be introduced before full eff…
Using Multiscale Molecular Dynamics Simulations to Obtain Insights into Pore Forming Toxin Mechanisms
Rajat Desikan, Amit Behera, Prabal K. Maiti +1
Pore forming toxins (PFTs) are virulent proteins released by several species, including many strains of bacteria, to attack and kill host cells. In this article, we focus on the ut…
The weakest link bridging germinal center B cells and follicular dendritic cells limits antibody affinity maturation
Rajat Desikan, Rustom Antia, Narendra M. Dixit
The affinity of antibodies (Abs) produced in vivo for their target antigens (Ags) is typically well below the maximum affinity possible. Nearly 25 years ago, Foote and Eisen explai…