Showing 2018Show all
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q-bio.GN2018
Detecting T-cell receptors involved in immune responses from single repertoire snapshots
Mikhail V Pogorelyy, Anastasia A Minervina, Mikhail Shugay +4
Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires…
q-bio.PE2018
Precise tracking of vaccine-responding T-cell clones reveals convergent and personalized response in identical twins
Mikhail V. Pogorelyy, Anastasia A. Minervina, Maximilian Puelma Touzel +11
T-cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remain…