5 papers
Immune Fingerprinting through Repertoire Similarity
Thomas Dupic, Meriem Bensouda Koraichi, Anastasia Minervina +3
Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine. However, the question of how person…
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
Anastasia A. Minervina, Ekaterina A. Komech, Aleksei Titov +10
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells and facilitating the…
Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones
Anastasia A. Minervina, Mikhail V. Pogorelyy, Ekaterina A. Komech +9
The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Previous studies show that secondary responses to the yellow fever…
Detecting T-cell receptors involved in immune responses from single repertoire snapshots
Mikhail V Pogorelyy, Anastasia A Minervina, Mikhail Shugay +4
Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires…
Precise tracking of vaccine-responding T-cell clones reveals convergent and personalized response in identical twins
Mikhail V. Pogorelyy, Anastasia A. Minervina, Maximilian Puelma Touzel +11
T-cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remain…