80 citations · 227 across the 9 of their papers we have counts for
10 papers
Full Three-dimensional Cell Geometry Matters for Epithelial Fluidization
Toshikaze Chiba, Jan Rozman, Matej Krajnc
Epithelial dynamics are often studied using two-dimensional models that omit cell height. Here, we investigate how this third dimension influences tissue fluidization driven by cel…
Emergent epithelial elasticity governed by interfacial surface mechanics and substrate interaction
Urska Andrensek, Matej Krajnc
During the life of animals, epithelial tissues undergo extensive deformations--first to form organs during embryogensis and later to preserve integrity and function in adulthood. T…
Basolateral mechanics prevents rigidity transition in epithelial monolayers
Jan Rozman, Matej Krajnc, Primož Ziherl
The mechanics of epithelial tissues, which is governed by forces generated in various cell domains, is often investigated using two-dimensional models that account for the apically…
Graph topological transformations in space-filling cell aggregates
Tanmoy Sarkar, Matej Krajnc
Cell rearrangements are fundamental mechanisms driving large-scale deformations of living tissues. In three-dimensional (3D) space-filling cell aggregates, cells rearrange through…
Wrinkling instability in unsupported epithelial sheets
Urška Andrenšek, Primož Ziherl, Matej Krajnc
We investigate the elasticity of unsupported epithelial monolayer and we discover that unlike a thin solid plate, which wrinkles if geometrically incompatible with the underlying s…
Morphologies of compressed active epithelial monolayers
Jan Rozman, Matej Krajnc, Primož Ziherl
Using a three-dimensional active vertex model, we numerically study the shapes of strained unsupported epithelial monolayers subject to active junctional noise due to stochastic bi…
Active instability and nonlinear dynamics of cell-cell junctions
Matej Krajnc, Tomer Stern, Clement Zankoc
Active cell-junction remodeling is important for tissue morphogenesis, yet its underlying physics is not understood. We study a mechanical model that describes junctions as dynamic…
Elasticity, stability, and quasi-oscillations of cell-cell junctions in solid confluent epithelia
Clement Zankoc, Matej Krajnc
Macroscopic properties and shapes of biological tissues depend on the remodelling of cell-cell junctions at the microscopic scale. We propose a theoretical framework that couples a…
Collective Cell Mechanics of Small-Organoid Morphologies
Jan Rozman, Matej Krajnc, Primož Ziherl
The study of organoids, artificially grown cell aggregates with the functionality and small-scale anatomy of real organs, is one of the most active areas of research in biology and…
Fluidization of epithelial sheets by active cell rearrangements
Matej Krajnc, Sabyasachi Dasgupta, Primož Ziherl +1
We theoretically explore fluidization of epithelial tissues by active T1 neighbor exchanges. We show that the geometry of cell-cell junctions encodes important information about th…