3 papers
physics.atm-clus2025
Contact cluster modeling of allosteric communication in PDZ domains
Emanuel Dorbath, Fabian Rudolf, Adnan Gulzar +1
Allostery, the intriguing phenomenon of long-range communication between distant sites in proteins, plays a central role in biomolecular regulation and signal transduction. While i…
physics.bio-ph2023
Log-periodic oscillations as real-time signatures of hierarchical dynamics in proteins
Emanuel Dorbath, Adnan Gulzar, Gerhard Stock
The time-dependent relaxation of a dynamical system may exhibit a power-law behavior that is superimposed by log-periodic oscillations. Sornette [Phys. Rep. 297, 239 (1998)] showed…
physics.bio-ph2020
Real-time observation of ligand-induced allosteric transitions in a PDZ domain
Olga Bozovic, Claudio Zanobini, Adnan Gulzar +6
While allostery is of paramount importance for protein regulation, the underlying dynamical process of ligand (un)binding at one site, resulting time evolution of the protein struc…