3 papers
physics.bio-ph2021
The Speed of Allosteric Signaling Within a Single-Domain Protein
Olga Bozovic, Jeannette Ruf, Claudio Zanobini +4
While much is known about different allosteric regulation mechanisms, the nature of the "allosteric signal", and the timescale on which it propagates, remains elusive. The PDZ3 dom…
physics.bio-ph2021
Sequence of Events During Peptide Unbinding from RNase S: A Complete Experimental Description
Brankica Jankovic, Jeannette Ruf, Claudio Zanobini +3
The photo-triggered unbinding of the intrinsically disordered S-peptide from the RNase S complex is studied with the help of transient IR spectroscopy, covering a wide range of tim…
physics.bio-ph2020
Real-time observation of ligand-induced allosteric transitions in a PDZ domain
Olga Bozovic, Claudio Zanobini, Adnan Gulzar +6
While allostery is of paramount importance for protein regulation, the underlying dynamical process of ligand (un)binding at one site, resulting time evolution of the protein struc…