4 papers
The Speed of Allosteric Signaling Within a Single-Domain Protein
Olga Bozovic, Jeannette Ruf, Claudio Zanobini +4
While much is known about different allosteric regulation mechanisms, the nature of the "allosteric signal", and the timescale on which it propagates, remains elusive. The PDZ3 dom…
Sequence of Events During Peptide Unbinding from RNase S: A Complete Experimental Description
Brankica Jankovic, Jeannette Ruf, Claudio Zanobini +3
The photo-triggered unbinding of the intrinsically disordered S-peptide from the RNase S complex is studied with the help of transient IR spectroscopy, covering a wide range of tim…
Nanosecond protein dynamics in a red/green Cyanobacteriochrome revealed by transient IR spectroscopy
David Buhrke, Kerstin T. Oppelt, Philipp J. Heckmeier +2
Over the last decades, photoreceptive proteins were extensively studied with biophysical methods to gain a fundamental understanding of their working mechanisms and further guide t…
Real-time observation of ligand-induced allosteric transitions in a PDZ domain
Olga Bozovic, Claudio Zanobini, Adnan Gulzar +6
While allostery is of paramount importance for protein regulation, the underlying dynamical process of ligand (un)binding at one site, resulting time evolution of the protein struc…