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q-bio.PE2024
Phenotypic heterogeneity in temporally fluctuating environments
Alexander P Browning, Sara Hamis
Many biological systems regulate phenotypic heterogeneity as a fitness-maximising strategy in uncertain and dynamic environments. Analysis of such strategies is typically confined…
q-bio.PE2024
Reducing phenotype-structured PDE models of cancer evolution to systems of ODEs: a generalised moment dynamics approach
Chiara Villa, Philip K Maini, Alexander P Browning +3
Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in disease progression and treatment failure. Accordingly, there has been increasing interest in…