11 citations · 20 across the 13 of their papers we have counts for
16 papers
A Physics-Conditioned Neural Operator for Generalization of Atrioventricular Valve Mechanics across Pressure and Tissue Properties
Shawn Koohy, Wensi Wu, Matthew A Jolley +1
Mitral and tricuspid regurgitation are the most common regurgitant valvular lesions, yet only a minority of severe cases undergo corrective surgery. Rapid assessment of valve mecha…
An Octahedral Fibrous Constitutive Model for Heart Valve Mechanics and Function
Nishan Parvez, Prashant K. Purohit, Wensi Wu
Fibrous soft tissues derive their nonlinear mechanical response from networks of extracellular matrix fibers. The organization of fibers and their load-bearing characteristics give…
An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM
Ryan T. Black, Steve A. Maas, Wensi Wu +4
Fluid-structure interaction (FSI) simulation of biological systems presents significant computational challenges, particularly for applications involving large structural deformati…
Biomechanically Informed Image Registration for Patient-Specific Aortic Valve Strain Analysis
Mohsen Nakhaei, Alison Pouch, Silvani Amin +8
Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid aortic valves, alter leaflet loading,…
Effect of Right Ventricular Outflow Tract Material Properties on Simulated Transcatheter Pulmonary Placement
Jalaj Maheshwari, Wensi Wu, Christopher N. Zelonis +9
FE simulations emulating TPV system deployment in patient-specific right ventricular outflow tracts (RVOT) assume material properties for the RVOT and adjacent tissues. Sensitivity…
A geometric feature tracking approach for noninvasive patient specific estimation of leaflet strain from 3D images of heart valves
Wensi Wu, Matthew Daemer, Jeffrey A. Weiss +2
Valvular heart disease is prevalent and a major contributor to heart failure. Valve leaflet strain is a promising metric for evaluating the mechanics underlying the initiation and…
Simulation of Transcatheter Therapies for Atrioventricular Valve Regurgitation in an Open-Source Finite Element Simulation Framework
Seda Aslan, Nicolas R. Mangine, Devin W. Laurence +8
Purpose: Transcatheter edge-to-edge repair (TEER) and annuloplasty devices are increasingly used to treat mitral valve regurgitation, yet their mechanical effects and interactions…
Integrated Open-Source Framework for Simulation of Transcatheter Pulmonary Valves in Native Right Ventricular Outflow Tracts
Christopher N. Zelonis, Jalaj Maheshwari, Wensi Wu +14
Pulmonary insufficiency is a consequence of transannular patch repair in Tetralogy of Fallot (ToF), leading to late morbidity and mortality. Transcatheter native outflow tract pulm…
Effect of Parametric Variation of Chordae Tendineae Structure on Simulated Atrioventricular Valve Closure
Nicolas R. Mangine, Devin W. Laurence, Patricia M. Sabin +9
Many approaches have been used to model chordae tendineae geometries in finite element simulations of atrioventricular heart valves. Unfortunately, current "functional" chordae ten…
ADEPT: A Noninvasive Method for Determining Elastic Parameters of Valve Tissue
Wensi Wu, Mitchell Daneker, Christian Herz +5
Computer simulation of "virtual interventions" may inform optimal valve repair for a given patient prior to intervention. However, the paucity of noninvasive methods to determine i…
Identifying heterogeneous micromechanical properties of biological tissues via physics-informed neural networks
Wensi Wu, Mitchell Daneker, Kevin T. Turner +2
The heterogeneous micromechanical properties of biological tissues have profound implications across diverse medical and engineering domains. However, identifying full-field hetero…
The effects of leaflet material properties on the simulated function of regurgitant mitral valves
Wensi Wu, Stephen Ching, Patricia Sabin +5
Advances in three-dimensional imaging provide the ability to construct and analyze finite element (FE) models to evaluate the biomechanical behavior and function of atrioventricula…
Effective Data Sampling Strategies and Boundary Condition Constraints of Physics-Informed Neural Networks for Identifying Material Properties in Solid Mechanics
Wensi Wu, Mitchell Daneker, Matthew A. Jolley +2
Material identification is critical for understanding the relationship between mechanical properties and the associated mechanical functions. However, material identification is a…
A Computational Framework for Atrioventricular Valve Modeling using Open-Source Software
Wensi Wu, Stephen Ching, Steve A. Maas +4
Atrioventricular valve regurgitation is a significant cause of morbidity and mortality in patients with acquired and congenital cardiac valve disease. Image-derived computational m…
A new engineering theory describing oblique free surface impact by flexible plates
Wensi Wu, Christopher Earls
Consideration of slamming loads within the structural design of planning hulls is of critical importance in ensuring adequate structural performance in order to avoid potential cat…
A Principled Approach to Design Using High Fidelity Fluid-Structure Interaction Simulations
Wensi Wu, Christophe Bonneville, Christopher J. Earls
A high fidelity fluid-structure interaction simulation may require many days to run, on hundreds of cores. This poses a serious burden, both in terms of time and economic considera…