3 papers
q-bio.PE2023
Hypoxia-related radiotherapy resistance in tumours: treatment efficacy investigation in an eco-evolutionary perspective
Giulia Chiari, Giada Fiandaca, Marcello Edoardo Delitala
In the study of therapeutic strategies for the treatment of cancer, eco-evolutionary dynamics are of particular interest, since characteristics of the tumour population, interactio…
q-bio.PE2023
Hypoxia-resistance heterogeneity in tumours: the impact of geometrical characterization of environmental niches and evolutionary trade-offs. A mathematical approach
Giulia Chiari, Giada Fiandaca, Marcello Edoardo Delitala
In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dynamics lies in the tumor-environment interaction. In particular, oxygen concentr…
q-bio.TO2020
A mathematical study of the influence of hypoxia and acidity on the evolutionary dynamics of cancer
Giada Fiandaca, Marcello Delitala, Tommaso Lorenzi
Hypoxia and acidity act as environmental stressors promoting selection for cancer cells with a more aggressive phenotype. As a result, a deeper theoretical understanding of the spa…