48 citations · 137 across the 6 of their papers we have counts for
5 papers · 1 filter
Insights into human evolution from large genetic biobanks
Jeffrey P. Spence, Roshni A. Patel
The development of large genetic biobanks with deep phenotyping and whole-exome or whole-genome sequencing is enabling an ever-deeper understanding of human evolution. Here we revi…
grenedalf: population genetic statistics for the next generation of pool sequencing
Lucas Czech, Jeffrey P. Spence, Moisés Expósito-Alonso
Pool sequencing is an efficient method for capturing genome-wide allele frequencies from multiple individuals, with broad applications such as studying adaptation in Evolve-and-Res…
Inference of Population History using Coalescent HMMs: Review and Outlook
Jeffrey P. Spence, Matthias Steinrücken, Jonathan Terhorst +1
Studying how diverse human populations are related is of historical and anthropological interest, in addition to providing a realistic null model for testing for signatures of natu…
Two-Locus Likelihoods under Variable Population Size and Fine-Scale Recombination Rate Estimation
John A. Kamm, Jeffrey P. Spence, Jeffrey Chan +1
Two-locus sampling probabilities have played a central role in devising an efficient composite likelihood method for estimating fine-scale recombination rates. Due to mathematical…
The site frequency spectrum for general coalescents
Jeffrey P. Spence, John A. Kamm, Yun S. Song
General genealogical processes such as - and -coalescents, which respectively model multiple and simultaneous mergers, have important applications in studying marine species,…