34 citations · 34 across the 5 of their papers we have counts for
6 papers
Condensation dynamics of sticky and anchored flexible biopolymers
Adam R. Lamson, Mohammadhossein Firouznia, Michael J. Shelley
Cells regulate gene expression in part by forming DNA-protein condensates in the nucleus. While existing theories describe the equilibrium size and stability of such condensates, t…
Mechanics and morphology of proliferating cell collectives with self-inhibiting growth
Scott Weady, Bryce Palmer, Adam Lamson +3
We study the dynamics of proliferating cell collectives whose microscopic constituents' growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a…
Using a Fast Adaptive Function Approximator to calculate Protein-Filament Binding Kinetics
Zihan Zhang, Adam R. Lamson, Robert Blackwell
The cytoskeleton, consisting of biopolymer filaments, molecular motors, and passive crosslinking proteins, provides the internal structure of cells that facilitate movement, growth…
Interpretable neural architecture search and transfer learning for understanding CRISPR/Cas9 off-target enzymatic reactions
Zijun Zhang, Adam R. Lamson, Michael Shelley +1
Finely-tuned enzymatic pathways control cellular processes, and their dysregulation can lead to disease. Creating predictive and interpretable models for these pathways is challeng…
Towards the cellular-scale simulation of motor-driven cytoskeletal assemblies
Wen Yan, Saad Ansari, Adam Lamson +3
The cytoskeleton -- a collection of polymeric filaments, molecular motors, and crosslinkers -- is a foundational example of active matter, and in the cell assembles into organelles…
Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors
Adam R. Lamson, Jeffrey M. Moore, Fang Fang +3
In cells, cytoskeletal filament networks are responsible for cell movement, growth, and division. Filaments in the cytoskeleton are driven and organized by crosslinking molecular m…