4 papers
Condensation dynamics of sticky and anchored flexible biopolymers
Adam R. Lamson, Mohammadhossein Firouznia, Michael J. Shelley
Cells regulate gene expression in part by forming DNA-protein condensates in the nucleus. While existing theories describe the equilibrium size and stability of such condensates, t…
Mechanics and morphology of proliferating cell collectives with self-inhibiting growth
Scott Weady, Bryce Palmer, Adam Lamson +3
We study the dynamics of proliferating cell collectives whose microscopic constituents' growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a…
Using a Fast Adaptive Function Approximator to calculate Protein-Filament Binding Kinetics
Zihan Zhang, Adam R. Lamson, Robert Blackwell
The cytoskeleton, consisting of biopolymer filaments, molecular motors, and passive crosslinking proteins, provides the internal structure of cells that facilitate movement, growth…
Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors
Adam R. Lamson, Jeffrey M. Moore, Fang Fang +3
In cells, cytoskeletal filament networks are responsible for cell movement, growth, and division. Filaments in the cytoskeleton are driven and organized by crosslinking molecular m…