1 citations · 1 across the 6 of their papers we have counts for
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stat.AP2022★ 1 cited
Backfilling Cohorts in Phase I Dose-Escalation Studies
Helen Barnett, Oliver Boix, Dimitris Kontos +1
The use of `backfilling', assigning additional patients to doses deemed safe, in phase I dose-escalation studies has been used in practice to collect additional information on the…
stat.AP2022
Dose Finding Studies for Therapies with Late-Onset Safety and Efficacy Outcomes
Helen Barnett, Oliver Boix, Dimitris Kontos +1
In Phase I/II dose-finding trials, the objective is to find the Optimal Biological Dose (OBD), a dose that is both safe and efficacious that maximises some optimality criterion bas…