Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-$\beta$ signaling

Niklas Kolbe, Lorenz Hexemer, Lukas-Malte Bammert +3

Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-$\beta$/SMAD signaling encodes var…