3 papers
physics.bio-ph2026
Reverse translocation of a nascent polypeptide through the ribosomal exit tunnels
Felipe C. Nepomuceno, Petr Chalupský, Michal Kolář
Before they mature, all known proteins translocate through the ribosomal exit tunnel in a form of extended or partially folded nascent polypeptide. This translocation occurs in the…
physics.bio-ph2025
Computer simulations of the bacterial ribosome using a general purpose coarse-grained model MARTINI
Josef Cikhart, Aneta Leskourová, Michal H. Kolář
Ribosomes are critical biomolecular nanomachines responsible for protein synthesis in all known organisms. The function and dynamics of ribosomes can be studied using molecular dyn…
physics.bio-ph2020
Atomistic simulations of the human proteasome inhibited by a covalent ligand
Michal H. Kolář, Lars V. Bock, Helmut Grubmüller
The proteasome is a large biomolecular complex responsible for protein degradation. It is under intense research due to its fundamental role in cellular homeostasis, and tremendous…