612 citations · 664 across the 9 of their papers we have counts for
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A mathematical model of systemic inhibition of angiogenesis in metastatic development
Sebastien Benzekry, Alberto Gandolfi, Philip Hahnfeldt
We present a mathematical model describing the time development of a population of tumors subject to mutual angiogenic inhibitory signaling. Based on biophysical derivations, it de…
Maximum Tolerated Dose Versus Metronomic Scheduling in the Treatment of Metastatic Cancers
Sebastien Benzekry, Philip Hahnfeldt
Although optimal control theory has been used for the theoretical study of anti-cancerous drugs scheduling optimization, with the aim of reducing the primary tumor volume, the effe…
Quantitative Analysis of the Tumor/Metastasis System and its Optimal Therapeutic Control
Sebastien Benzekry, Dominique Barbolosi, Assia Benabdallah +2
A mathematical model for time development of metastases and their distribution in size and carrying capacity is presented. The model is used to theoretically investigate anti-cance…